Generative AI Startups funded by Y Combinator (YC) 2025

Anto is building a foundation model for microbial communities, making the gut microbiome computable for the first time. We predict drug toxicity and efficacy across diverse populations and fix drugs so they work for everyone — solving the hidden root cause of most drug failures. Founded by Arvid (Broad Institute of MIT and Harvard; Nature-published researcher who pioneered quality-aware, goal-directed sparsification) and David (Harvard Medical School Gastroenterology, J&J), second-time founders who published the breakthrough at leading machine learning AI conferences and Nature.

Expected Parrot helps companies simulate their customers with AI agents to explore pricing, product, marketing, communications and other scenarios at scale. Our open-source library and no-code web app let you design custom agent personas and conduct interviews and surveys with them using LLMs of your choice to generate results and reports. Everything is cached and reproducible, and you can send the same surveys to human respondents to validate results in the same interface.

Absurd makes AI brand and performance ads at scale. Our last video for Kalshi ("Election Day") did 1M+ views, and we average 300K+ organic views across all videos. Our clients include Kalshi, Replit, Reforge, Gumloop, Micro1, and a couple YC and HF0 startups. We do this with a multi-agent orchestration layer to create production-quality videos in 72 hours. These agents collaborate with your team to plan and generate every scene on an interactive canvas. From the canvas, your team can watch image frames and video renders come to life in real time — commenting, iterating, or generating new ideas alongside the agents. Try it today at absurd.com

LunaBill is building AI Voice callers for healthcare billing teams. Insurance claim follow-up calls account for the 80% of the daily workload of a healthcare billing team, with each call averaging 30 minutes. Since our launch in July we are now at $764K in contracted ARR, of which $428K is live revenue and the rest will go live by January 2026. Our customers see a 10x increase in claims followed up per biller in the first week and we have converted 100% of pilots to paying customers. We have automated 50,000+ calls and signed partnerships with top healthcare leaders like UC health systems, Mayo, Experian Health and more. The founders have known each other for over a year. Suhail is a 2x founder, with 3+ years of experience building in healthcare including operating a medical billing company with 200+ healthcare clients. David founded Skiesoft, Taiwan’s biggest healthcare AI scribe company, used by 120k+ healthcare professionals. He also worked as a data scientist at UCSF, building models to audit medical-coding accuracy. Yash was a researcher at various hospital systems including Mayo Clinic.

Pixley is the first platform where kids can turn their drawings and ideas into fully animated cartoons in minutes. In just 3 weeks after launch, over 1000 families across 75 countries have already started creating stories. We’re starting with a clear wedge: personalized kids’ entertainment. Parents are tired of overstimulating, low-value content from YouTube and Netflix. Pixley gives them safe and personalized stories that encourage learning and imagination. But kids’ cartoons are just the beginning. As video generation improves, all video content will shift from manual production to being personalized and generated. Our long-term goal is to build the AI Netflix: a platform where shows and movies aren’t recommended, but instead generated around each viewer’s interests and habits. We’re 19 year old CS dropouts who’ve known each other since elementary school and won 4 hackathons at 15. After seeing AI flood the internet with low-quality content, we created Pixley – a safe, personalized way for kids to turn their ideas into animated stories.

Koyal is an Agentic AI Filmmaking Platform that allows you to seamlessly convert script or audio into personalized, visually compelling stories. We’re a team from Carnegie Mellon, MIT and Meta, with experience in AI video generation. https://koyal.ai builds directly upon our published research at the AI conference NeurIPS in December. We’ve been covered in the international press for our patented secure personalization protocol CHARCHA: the genAI captcha. Announcement: https://x.com/meh_agarwal/status/1965866965425348687 Demo: https://x.com/meh_agarwal/status/1965137062119752099 We currently have paid pilots with the biggest global music labels, podcasts and production houses, and just launched our public beta at beta.koyal.ai We recently concluded a pilot with Universal Music and T-Series (world’s largest music label) alongside Bollywood production houses like Maddock Entertainment, and Collective Artists Network! As part of that, we launched 5 music videos for Grammy and Oscar winning artists like A R Rahman, Ricky Kej and Shankar Mahadevan all crossing 1.5 million views! We've recently built SOTA capabilities in (i) multilingual script to audio to video, (ii) Agentic lip-sync with dynamic movement & (iii) Multi-character consistency.

Bear helps companies capture and convert the highest-intent leads on the internet - visitors clicking from ChatGPT, Perplexity, and other AI agents. Bear owns the entire funnel from agent discovery to conversion.

We build red-teaming agents that help developers fix their RL environments and improve their agents. Our customers are tired of being bullshitted by their agents.

Outsourced IT is a $350B industry running on 10-20% margins. We're building AI employees to help them solve support tickets faster and increase margins to 70-80%. Yolanda worked as a Senior Support Engineer at Netflix. Her team ran 3x more efficiently than average outsourced IT companies. We're now bringing the automation Netflix has to 150K companies globally.

Bezel helps fashion brands create virtual photo/video shoots with AI. Upload images of clothes, select the human you want to model it, and Bezel generates pictures and videos that rival a full studio production. Every detail of the clothing is rendered flawlessly. Try it for yourself.

At Pleom, we’re building AI hardware devices that everyday consumers can talk to — devices that understand your context and handle real-world tasks. We’re going head-to-head with OpenAI and io, moving faster to market and capturing mindshare first. Today, Pleom is a website. Tomorrow, it will be integrated into our family of hardware devices.

Our mission is to build self-improving AI agents. We're here to close the last mile reliability gap. Through calibrated llm judges and automatic evaluations, we help companies optimize their agents 10x faster than doing manual experimentation.

Qualify.bot helps commercial lenders and loan brokers process business loan applications with 4x higher conversion rates. Our AI voice calls eliminates 8+ hours of manual work per loan, from lead qualification to document collection & follow-ups.

Doe is where AI agents actually do your work. Connect your tools, tell Doe what you need, and agents handle it. When you want to do something yourself, Doe makes you faster and smarter. The boring stuff disappears. Everything else gets better.

PARES is the single platform commercial real estate brokers need for their entire workflow, from chasing leads to closing deals and everything in between. With our platform, brokers can: 1) Automatically update real-time transaction data in our CRM 2) Create lists of target properties, skip-trace, and easily navigate outbound calls 3) Underwrite deals with our AI Underwriting Agent 4) Create OMs/BOVs in minutes with our AI Marketing Agent Check us out at https://www.pares.ai/

Cleon is building an AI-native software implementation platform to speed up customer onboarding, beginning with a focus on ingesting complex Excel files with agentic AI. B2B SaaS companies have millions of dollars of contracted revenue sitting behind implementations. Cleon handles everything from the big picture (generating requirements and aligning stakeholders) to the details (data cleaning and schema mapping). The team consists of Alexandros (ex-athlete in rowing and engineer at a proptech startup), Rohan (engineer at a fintech startup with long implementations and at an SAP code migration startup), and Ric (banker at RBC and enterprise sales at Palantir).

Kashikoi is a simulation engine to benchmark AI agents. We generate CPU friendly world models that autonomously interview agents and generate deep behavioral assessments. We built a similar technology at Moveworks which was used to ship 250+ enterprise agents to customers daily.

Our AI Chief of Staff gives CEOs and busy executives instant visibility into project progress, team performance and key company metrics. Eliminating status updates and saving execs 10+ hours a week.

The LLM Data Company is a research lab studying post-training data. We work with frontier AI teams to create bespoke tasks, rewards, and environments for models to play and learn at scale.

Cohesive is the agentic CRM for blue collar businesses like janitorial, pressure washing, landscaping, HVAC, and pest control businesses. Cohesive fully automates sales and marketing outreach to local businesses and property owners in the service area, helping local service businesses grow even while servicing clients in the field.

Aviro is building the infra for enterprise AI agents to continuously upskill to handle complex workflows. Our runtime layer, Cortex, guides agents in real time, anchoring them to enterprise standard operating procedures (SOPs) and compounding their abilities through reinforcement learning. By embedding operational expertise directly into agent runs, Aviro ensures agents reliably follow company workflows, adapt on the fly, and get smarter with each task.

Blueshoe is an AI platform for legal research and reasoning designed to capture the structure of legal thought and allow users to work directly within the logic of caselaw. By combining advanced AI with curated legal and proprietary data pipelines, the system allows users build and test arguments with unprecedented clarity.

Auctor is used by leading solution engineers, system integrators, and professional services teams. Our AI agents capture requirements, generate aligned artifacts, and streamline discovery to deployment—turning weeks into hours.

LineWise is building an AI assistant for manufacturing teams to operate and resolve production issues, from defects to breakdowns. LineWise automatically extracts frontline know-how from live video recordings, turning them into structured SOPs and training guides. It also ingests generated SOPs, machine manuals, and past breakdown logs to suggest the most probable root causes when issues occur. Operators receive step-by-step guided troubleshooting, and as they confirm outcomes, LineWise learns from each resolution - converting every fix into a reusable playbook and proactively recommending preventive actions to cut future downtime.

Dollyglot is like Character.ai but with real time video avatars. Turn a photo and a voice into a real friend. Speak with Harry Potter about Hogwarts or brainstorm ideas with Elon Musk!

Instead of navigating complex menus or learning new tools, creatives can simply describe their vision in natural language—“Draw me a Swiss mountain lake. Now make it sunset. Add a boat. Now animate it.” Awen leverages AI reasoning to understand creative intent through voice. Our goal is to redefine how creatives engage with AI technology, balancing power and ease of use for both professionals and newcomers.

Tergle builds AI to replace Auditors.

Truffle AI makes it easy for developers to integrate AI agents into any software application. We do this by exposing agents as simple APIs that can be called from anywhere. Developers have used Truffle to add customer support agents into WhatsApp and analytics agents into Slack.

Miyagi Labs is an AI-powered exam prep platform that helps students ace tests like the SAT and ACT through our AI tutor, personalized study plans, thousands of practice questions, and realistic practice exams. We’re building the platform we wish we had when studying for exams. No more running out of practice questions. Track your progress as your rating in different exam categories increases, and know exactly what you need to practice most. We envision a world where students anywhere can come to Miyagi to ace their exams and receive personalized, world-class AI tutoring designed to unlock their full potential.

assistant-ui helps frontend developers add AI chat to their apps. Our product is used by several dozen companies, like LangChain, Stack AI, Browser Use, and Athena Intelligence. We're building an open source Typescript/React library and a backend as a service, with first class integrations into popular agent frameworks like LangGraph and Vercel AI SDK.

TrainLoop makes it effortless for developers to supercharge LLM performance through reinforcement learning.

Calltree makes enterprise-grade AI support reps for call centers. Our AI reps take voice calls and chats like other AI support agents but can also use internal enterprise tools like a homegrown CRM or internal dashboards, like the highly trained humans working there today.

Operand is building an AI to replace traditional consulting. We help businesses make better decisions by deeply analyzing their data across all sources—something consultants can’t do at scale. We’re starting in e-commerce and retail, where the businesses’ high data density and real-time feedback loops allow us to show impact fast. Our first capability is pricing and discount strategy. Operand considers everything—competitor pricing, ad strategy, inventory, and more—to ensure businesses maximize profit. And unlike other AI solutions, every Operand result is verified by human experts, including ex-MBB consultants, so you get actual impact, not just AI hype. We’re already generating 6-figure P&L improvements for early customers.

Trava is building AI agents for global trade compliance. Importers lose billions each year to duty overpayments and filing errors. Trava audits customs entries and automates classification to help importers protect margins and stay compliant at scale.

Sennu's AI agents automate Salesforce functional testing. Just connect your user stories and we'll take care of the rest.

Paragon is the AI growth engine for distributors and manufacturers, freeing up staff and growing revenue on autopilot.

City building departments are understaffed and overworked. Meanwhile, builders lobby to remove power from building departments. Because building departments are usually the only profitable/self-sustaining branch of a local government, this is problematic. Permitify allows city build-plan reviewers to 10x their productivity covering the labor shortage, reducing the time required to issue a building permit, and allowing the city government's only profitable branch to stay intact.

a0.dev is a platform that helps mobile developers build high quality apps in days instead of weeks by generating custom react native projects. We've launched top ranking apps that have been used by hundreds of thousands, and now we're creating the tools we wish we had to build faster.

ThirdLayer is an applied research and product lab building the next interface for human–AI collaboration. Our first product is Dex, an AI copilot for the browser. Think Cursor for knowledge work, optimized for speed and embedded directly where you work. Most web agents are built for set-and-forget tasks. But real work is fluid and messy—spread across tabs, tools, and evolving decisions. Dex transforms your browser into an intelligent, multimodal workspace that understands your intent through voice, text, and action. It enhances familiar interfaces, automates tedious steps, and removes the friction of handoffs. Beneath the surface, Dex is more than a browser agent — it’s a foundation for: ● Long-term, cross-modal memory grounded in real workflows ● A new interaction layer to replace static UI with a collaborative canvas ● Personalization: understanding how individuals approach tasks and navigate software We're building the infrastructure for adaptive, intent-aware systems that work the way you do.

Alice turns generic course materials into personalized learning and exam prep using AI. We’re Duolingo for exams, and more than 10k college students have already used Alice. Kim, the CEO, is a domain expert in education with more than 10+ years of university teaching experience. He is also technical by background. MRR is $20k, growing +10% week-over-week the last 8 weeks Alice's core market opportunity is +$10b, with the global education market being almost $10trillion. As AI starts to disrupt education, Alice will use in-built network effects and virality in its product to create a global winner. Go Alice. Thank you!

Confident AI allows companies of all sizes to benchmark, safeguard, and improve LLM applications, with best-in-class metrics and guardrails powered by DeepEval. Built by the creators of DeepEval (4.3k stars, >400k monthly downloads), Confident AI is able to offer battle-tested, open-source evaluation algorithms while providing the infrastructure needed for teams to stay confident their LLM systems.

Docs are integral to a great customer experience, but managing them is a challenging, multi-team effort. The most successful companies recognize that fantastic docs drive adoption and bad ones cause customers to churn. Promptless is used by fast-growing startups and Fortune 500 enterprises alike to automatically update docs based on feature releases, support tickets, internal Slack conversations, and more. Promptless is designed to be flexible—it can integrate with any docs platform, be triggered automatically from many workflows, and can pull in context from any internal knowledge source. With Promptless, documentation becomes a strategic advantage for growth, not a bottleneck or a liability.

Avora helps dental groups (DSOs) boost case acceptance and institutionalize clinical excellence. We deploy agents that listen to appointments, identify coachable moments, and chart notes to save provider time.

We’re building browser-native infrastructure that makes software creation production-ready end-to-end. Today’s AI tools can scaffold code, but they fail on the critical workflows that actually get products into production — provisioning, auth, QA, and compliance — all of which happen inside the browser. Our system makes these workflows deterministic, reproducible, and automatable, so both agents and humans can go from idea to a production-ready app. The opportunity is massive: billions of dollars of value locked up in workflows that today block non-technical founders and slow technical teams. We’re building the infrastructure layer that makes production possible.

Pearson builds AI agents to automate corporate transactions. Large law firms use us to run gigantic books of businesses with AI, reducing their cost of delivery 40-60%. We work with Orrick as our first design partner, starting with M&A due diligence and financings. $3-6T dollars flow through corporate transactions a year and lawyers take home 1-3% as their cut for every transaction ($150B / year). In the long run, we will capture 50% of the corporate transaction market with the top 30 law firms. We will then provide our AI to companies so they can execute these transactions themselves.

The AI platform that has everything you need to build, monetize, and deploy full-stack websites in minutes. Beautiful UIs, auth, database, payment processing, deployments, and more natively integrated in one place.

BrowserBook makes it easy to reliably automate the web. It's a Jupyter-style IDE for browser automation that combines a live browser, executable code cells, and an AI coding assistant to generate Playwright scripts that are deterministic by default. Developers use BrowserBook to build, debug, and deploy robust web automations, powering AI agents, QA workflows, and data operations.

Kura breaks 87% on the WebVoyager Benchmark. That is 31% better than Claude's Computer Use demo and 14% better than the previous State of the Art. In 10 years there will be more AI agents on the internet than humans. Kura is SOTA for giving AI agents the tools for interacting with websites.

Melder is an Excel add-in that brings AI functions and document support into your spreadsheets. Upload files directly into cells, use smart formulas like =GEN, and build automations—all without leaving Excel. Core features: - File-to-Sheet: Drop PDFs directly into cells, then reference them in formulas. - AI-Powered Functions: Write formulas like =GEN() or =EXTRACT() to summarize, classify, and analyze content. - Chat Assistant: Use our AI assistant to help build your sheets or answer questions from your data, live in the workbook. Business users use Melder to: - Accelerate diligence by extracting insights from data rooms - Review contracts by identifying key terms and clauses instantly - Run market research by pulling information from competitor websites - Synthesize transcripts by generating summaries from interviews and calls Melder brings the power of structured spreadsheet logic to the messy, unstructured data world—no coding needed.