Digital Health Startups funded by Y Combinator (YC) 2025

Saffron Health is building AI agents that automate specialist referrals for primary care. Primary care staff spend hours each day on tedious coordination work: searching for in-network specialists, filling out authorization forms, and chasing down medical records. Saffron's agents find available in-network providers, complete prior authorizations, and help patients book appointments, which lowers administrative costs and improves access to care.

Kaigo Health provides an AI-powered outpatient care management platform that automates and scales remote care management for Medicare patients including post-discharge followups, ongoing check-ins, and monitoring. Using phone calls as an age-friendly interface, we aggregate patient responses, voice biomarkers, and remote patient monitoring data for powerful preventative and proactive healthcare.

We deliver high-quality, cost-effective healthcare to employees through text. Employers cut 10–20% of healthcare spend. Employees get concierge care that improves outcomes. Our AI agents analyze clinical data to spot upcoming care. We treat common conditions through our virtual clinic. For more complex care, our agents find the best in-network providers using millions of price and quality data points, and handle end-to-end appointment booking. Employees are rewarded for choosing high-value care through copay reimbursements. We're rolling out to thousands of employees across multiple employers for the 2025-2026 plan year. Our goal is to build AI-native infrastructure that powers the next-generation of health insurance, starting with cost containment.

Nori is a concierge-level AI health coach in your pocket. It takes all of your health data—Apple Health, medical records, wearables, everything—and boils it down into a personalized daily plan. Users love it: “It's truly one of the best apps and I check it first every day. Since using Nori, I've been limiting devices in bed and eating earlier—and I'll be damned if it's not working... I started getting more deep sleep, my resting HR dropped to 43, my recovery improved.”—Jen, Nori user"

Play Health is building a perimenopause care platform to provide women and their providers with the tools they need to relieve symptoms fast. It is led by technical, second-time, YC-backed founders Andrea Mazzocchi, PhD and Ian Miller, with an exit and a unicorn between them. Over 30 million women in the U.S. are experiencing perimenopause symptoms, spending an estimated $15B+ annually on symptom management. Despite this most only receive generic solutions and struggle to find effective symptom relief. We're bringing evidence-based perimenopause care to women through partnerships with medical practices and employer and health benefits programs. Our platform integrates personalized symptom, medication, and lifestyle data to generate AI-powered insights and clinical protocols, enabling providers to deliver specialized care. Every clinical interaction enriches our longitudinal dataset allowing us to create better outcomes for patients, deeper insights for providers, and expand into women’s health broadly. This also enables us to partner with pharma and biotech companies developing therapeutics and diagnostics for women's health.

Paratus Health is the AI operations layer for outpatient clinics. We build autonomous agents that don’t just assist staff - they replace them, fully handling front desk calls, patient intake, insurance verification, documentation, and billing prep. Everything is deeply integrated into EHRs like Epic and Athena, eliminating the need for fragmented tools and manual work. No toggling between systems. No busywork. Just one intelligent system running your clinical operations - faster, smarter, and more profitably than ever before.

G LNK is an AI-powered platform simplifying how healthcare companies connect with the relevant medical professionals. Our proprietary matching and ranking models instantly identify the most qualified experts, accelerating drug development and commercialization. Designed with compliance at its core, G LNK ensures every connection meets strict regulatory and ethical standards—empowering companies to innovate faster with confidence.

Amby Health automates billing and quality reviews for ambulance agencies (EMS), replacing large back-office teams with AI. We analyze patient reports in seconds—not months—accurately coding claims and identifying liability and care risks while eliminating costly, error-prone manual processes.

HealthSpark empowers physical therapists (PTs) to start, run, and grow their own independent practices. Our AI-native “business-in-a-box” takes care of the administrative work—credentialing, insurance billing, patient onboarding, documentation, and scheduling—so PTs can focus on patient care, not paperwork.

FutureClinic is a platform that makes it easy for any doctor to open their own digital clinic. Our AI assistant takes a comprehensive medical history using an empathic chat or voice-based interface, uses sophisticated medical reasoning to narrow down likely diagnoses, and produces evidence-based treatment suggestions for each patient. Licensed doctors then review the text-based summaries of the cases our AI provides, and choose how to manage the patients. In this fashion, we're able to deliver end-to-end healthcare in a way that makes personalized, expert healthcare scalable to 8 billion people around the world.

HYBRD helps you get stronger and faster. It pulls in all your training data, from every wearable and workout tracking app you use, and uses it to personalize training plans specifically to you and your goals Existing products tend to focus on only one type of exercise (either cardio or strength), leaving hybrid athletes juggling disconnected tools. As hybrid athletes themselves the founders found this frustrating and set out to build the unified approach they needed for their training. Three of HYBRD’s founders previously worked at WHOOP, each leading teams across product, growth and analytics. Ruiters, the CTO, was a senior tech lead at AWS. In parallel, Mats was a member of the US national rowing team and Ben, Shoe and Ruiters have all completed Ironman 70.3s. The team's VP of tech/founding engineer Michael rowed at Cornell and is ex-WHOOP as well.

We empower healthcare providers, starting with emergency physicians, with instant access to up-to-date evidence-based answers. Our platform cuts through the noise to deliver trustworthy medical information 10x faster, revolutionizing clinical decision-support.

All-in-one RTM platform designed for physical therapy and powered by AI

Clarion is building the most advanced AI communication layer for healthcare. Our AI agents handle the overwhelming volume of calls and messages that clinics face daily—from scheduling to billing to prescription refills—freeing staff to focus on patient care. We're an in-person company based in New York. Today, clinics miss 30-40% of inbound calls due to staffing shortages. We're solving this by automating complex workflows end-to-end, already serving tens of thousands of patients monthly across virtual care companies, health systems, and a $5B health insurance company. We've raised $5.4M from Accel, Y Combinator, Sequoia (scout), and healthcare founders from Ophelia, Medallion, and Counsel Health. Our founders bring both clinical and technical expertise—our CEO Ryan is a Stanford/Harvard-trained physician who was on the founding teams of Two Chairs and Ophelia, while our CTO Jeffrey built voice AI at Amazon Alexa and led AI/ML teams at Salesforce. Join us as we transform healthcare communication—creating a future where patients get faster resolutions and providers reclaim time for what matters most.

Kabilah is the most trusted enterprise-grade AI platform designed specifically for nursing workflows. We reduce burnout, enhance system efficiency, and enable high quality care.

At Verse Therapy, we're dedicated to making quality speech therapy accessible for everyone by empowering speech-language pathologists (SLPs) to launch and grow their own independent practices. We help therapists focus on what they do best—providing compassionate, personalized care—by taking care of the administrative tasks that often lead to burnout. Through thoughtful marketing and partnerships with care organizations like rehab centers, we connect SLPs with individuals who need their expertise. Our AI-enabled back office streamlines insurance processing, scheduling, and documentation, reducing non-therapy overhead. We're now live in 10 states with over 35 dedicated therapists and are in-network with leading insurance providers, making it easier for clients to receive the support they need.

Aidy is a mobile app that helps people live fuller lives with chronic health conditions, beginning with Inflammatory Bowel Disease (Crohn’s Disease and Ulcerative Colitis). Our app lets users easily log their symptoms, diet, and treatments, then uses clinical indices to track disease severity and trends over time. Aidy excels at identifying patterns between diet, treatment adherence, and symptoms, giving our users a much more comprehensive and up-to-date picture of their condition to supplement clinician care. Previously in our careers, both Max and Peter worked in health in different capacities. At the Rockefeller Foundation and the United States Senate, Max worked in public health policy and COVID-19 response, while Peter worked as an ML researcher for a number of biotech companies. After a lengthy “pivot hell” we decided to finally listen to a friend with IBD who insisted that there weren’t any decent apps to help people live with the disease. Pretty quickly, we discovered how LLMs and regular structured questionnaire responses could provide a level of patient empowerment not possible before for chronic diseases. From there, Aidy was (re)born!

Over 80% of maternal mortalities were preventable with earlier intervention. Currently, doctors miss >50% of moms who have life-threatening complications and wait until labor to start doing manual risk assessments, at which point it's too late. Elythea's proprietary ML models catch life-threatening obstetric complications (like postpartum hemorrhage, preeclampsia/eclampsia, emergency c-section, preterm labor, and more) as soon as the first visit. We automatically analyze relevant demographic and clinical risk factors, flag high-risk patients, and provide evidence-based interventions, giving doctors months in advance to intervene and prevent complications from ever happening. Our global clinical studies have shown that we can catch 3x more complications than clinical judgment 10x sooner.

Shasta Health builds AI agents to handle patient calls, verify insurance and automate admin tasks for healthcare clinics

MediSearch gives direct answers to medical questions based on trustworthy sources.

Medical practices struggle with front desk shortages and nonstop admin work—ringing phones, scheduling mishaps, intake errors, and billing headaches. The result? Overworked staff and less time for patient care. Decoda Health’s AI platform takes over 80% of these tedious tasks, handling calls, scheduling, and payments while alerting staff only when necessary. By reducing chaos and streamlining operations, teams can focus on what truly matters—providing exceptional patient care.

Sohar Health is an AI-driven front-end RCM solution that transforms insurance verification processes for healthcare providers, enabling faster patient conversions and reducing administrative workloads. With a 95% automation rate, our API-first platform seamlessly integrates into existing workflows to provide real-time claim accuracy and eligibility checks. Key performance metrics showcase the power of our technology: Median latency of just 6 seconds, ensuring real-time eligibility; over 90% of checks returned within 30 seconds for increased patient conversion; 96% accuracy in identifying and verifying benefits details; Industry-leading 99% accuracy for eligibility determination; >90% carve-out detection rate, mitigating surprise billing risks; a 60% success rate with our Insurance Discovery API, helping identify coverage for self-pay patients. Our customers include outpatient clinics, specialty practices, and digital health platforms looking to streamline front-end claim management. By reducing errors and maximizing clean claim submissions, Sohar Health empowers healthcare organizations to convert and retain more patients, reduce operating costs, and increase their top-line revenue.

Healthtech-1 automates repetitive processes for healthcare systems. We’re starting with the world’s most famous: the NHS. We’re already live in over 1,400+ primary care practices. Based out of Raj's parents' Primary Care practice the Healthtech 1 team are systematically digitising the repetitive processes they experience everyday, saving thousands of hours of staff time. Why now? The UK's National Health Service (NHS) delivers free healthcare in 590 million patient contacts every year. Post-pandemic, Britain's most treasured institution is in crisis. Patient satisfaction is at 25 year low and 1/7 staff are applying for Non-NHS jobs fuelling an 11% recruitment gap. By digitising the 100s of repetitive processes in healthcare, Healthtech 1 will reverse the trend, and produce the world's most productive health care system.

Say what you're going to do, when you're going to do it, and how much money you'll forfeit if you don't do it. Send photo or timelapse evidence of you completing the habit by the time you set, or we take your money. Eg, I could set it to go to the gym (or meditate for 30 mins, or take a photo of a sent email, or of a max amount of calories on MyFitnessPal) tomorrow at 6am, or lose $30. If I don't send photo evidence in the gym (that we manually approve), I lose $30.

Loula is a software platform and national provider network for independent birth & postpartum doulas to boost their practices by accepting health insurance. Doulas typically operate outside of the traditional healthcare system and face an enormous learning curve and administrative burden when trying to accept insurance. This is why we created Loula. Starting with doulas in California, Loula handles their credentialing, contracting, and revenue cycle management so that they can focus on delivering the best quality care to their clients.

Kivo Health provides AI-powered virtual care for chronic lung disease patients. We offer an Medicare-covered clinical program that improves symptoms and reduces costs of care.

We empower clinicians with our AI platform for developing differential diagnoses and drafting clinical plans.

KemNet supplies pharmacies with premium reformulations of popular drugs that are more useful for specific groups of patients. For example, more than 30 pharmacies rely on KemNet to supply reformulated products for erectile dysfunction that work up to 8 times faster than alternatives. In addition to sexual function, products reformulated for novel drug delivery and supplied on KemNet include medications for hair growth, pain, weight loss and women's health.

We’re on a mission to leverage AI and voice technology to solve inefficiencies and revenue leakage in our healthcare system. With the rise of EHRs, the manual documentation burden on doctors has never been higher, leading to burnout and fatigue and high attrition rates. Assigning the correct diagnosis and billing codes is crucial for proper reimbursement and patient care, but medical coding is becoming more and more complex each year with growing numbers of codes (over 145,000 now), and doctors are unsupported by current technology to keep up with its ever increasing requirements. $125 billion is left on the table each year by healthcare organizations due to improper documentation and coding. Knowtex creates visit notes with up-to-date and accurate reimbursement codes from doctor-patient conversations, allowing the doctor to focus on patient care and preventing revenue leakage for hospital systems through standardized, transparent, and accurate documentation.

Malama offers doula-led holistic support during and after pregnancy at no cost to patients. Malama is in-network with Aetna, UnitedHealthcare, Anthem, Kaiser, and several Medicaid Managed Care Plans. Malama is backed by the Stanford d.school, Y Combinator (S22), Alpine Investors and more.

Dr. Treat is a tech enabled modern veterinary care company offering virtual and in-clinic services to pet parents. We are building the largest pet health company powered by technology and driven by data to offer highly personalized & preventative care for every pet.

Metriport provides real-time access to comprehensive medical data for 300M+ individuals across the US. Our open-source intelligence platform helps organizations access, analyze, and exchange patient data while integrating with all major healthcare IT systems. If you’ve been to doctors in the US, you may have encountered the problem: how does a healthcare provider get access to your up-to-date medical history to treat you properly? Reliance on archaic methods is still the norm: typically, you or your provider need to call the facilities where you’ve previously received treatment (assuming you remember them all), just to have them send your records via fax (yep, fax). This can take weeks, only then to have a provider sift through hundreds of pages of unstructured docs, just to figure out basic things like your active medication list, what conditions you may have, latest lab results, etc. This not only delays care—it can cause improper treatment, since the medical history is critical for informing treatment decisions. Metriport integrates fragmented medical data from thousands of sources—including both national and state/regional Health Information Exchanges (HIEs), ADTs, EHRs, pharmacies, and labs—through a single API connector. The platform then standardizes, deduplicates, and enriches this data to create a comprehensive longitudinal patient record, with AI-powered clinical summaries. Along with a rich understanding of patient health history, healthcare providers also get realtime updates about their patients' health through Metriport. This includes getting notified when a patient is discharged from the hospital, picks up their prescription from the pharmacy, or has a new lab result available. Through this data, care teams get insights across their patient population, helping with 30-day readmissions prediction, care gap closure, risk adjustment, and more. On top of all of this, Metriport enables healthcare organizations to share net-new clinical information back to all major healthcare IT systems, and to become interoperable with popular EHR systems such as Epic, Cerner, athena, eClinicalWorks, and many more—forming an internet for healthcare data. Metriport improves both patient and provider lives at the point-of-care, supporting use cases such as medication adherence, transitions of care management, chart prep, and much more. If you want to do work that matters, get in touch with us today.

Junction is an API for at-home health data that makes it easy for health tech companies to collect data from 100's of wearable devices and deliver at-home test kits to their users. Healthtech companies need lab data as well as wearable data, and we give them access to both through a single line of code.

India's leading digital health destination for Dermatology, Nutrition & Wellness. A multi-condition health platform providing Telehealth, AI-powered treatment plans, and Rx-grade products. Our virtual care is entirely science-based and personalized to each patient, based on prescription history, medical parameters, family history, lifestyle, surroundings and preexisting health issues.

Nest is a lab-agnostic, comprehensive solution for organizations to launch and implement large-scale genomic programs. The platform includes the ability to triage, consent, and counsel patients for genetic testing, provide EMR-integrated clinical decision support for providers managing patients with genetic results, and manage patients’ clinical needs across the continuum of care.

Mederva helps everyday people extend their healthspan through AI-powered precision medicine and behavioral therapy. We partner with clinics to assess risk, create personalized health blueprints, and guide patients step by step toward better health—fully reimbursed by insurance.

Current Description: RTHM provides virtual-first care for complex illness including Long COVID, ME/CFS, POTS, and mast cell activation. Many clinics focus on teaching patients how to better cope with symptoms, which is helpful, but we don’t stop there. We develop collaborations & partnerships so our patients access to the most promising testing and root-cause directed early therapies for their illness(es) with the goal of simplifying and streamlining the most efficient and effective clinical pathways so they can be scaled in the form of low cost online modules overseen remotely by clinicians. In conjunction with clinical care, RTHM operates a clinical lab and collects deep molecular data with robust clinical context to develop AI-powered diagnostics and better ways of predicting which treatments may work best for whom.

Adoption of Telehealth 1.0 has dropped to <5% because it's inefficient and unintelligent. Ankr uses generative AI to recreate functions of clinic staff including front desk, medical assistants and scribe. This allows Doctors to "spin-up" virtual clinics on-demand, anytime, anywhere. An average clinic using Ankr generates $1M in new revenue/year. We integrate with all top EHRs and work with all types of clinics in mid- to large-sized healthcare organizations.

At Tuva Health, we make open source software that cleans and transforms messy healthcare data. We’re founded by Aaron Neiderhiser and Coco Zuloaga, former senior execs from Health Catalyst and Strive Health. We realized data transformation and data quality is the fundamental problem preventing the healthcare industry from building scalable data products. We launched Tuva and joined the W22 batch of Y Combinator to solve this problem for the entire industry. Since January 1st, we signed our first customer (paying $10k per month) and completed the first major release of the Tuva Project. At Tuva, our goal is to (1) become the open standard for healthcare data transformation and (2) build the data network for multi-site benchmarking, research, and machine learning on top of this open standard.

Starling is building a urine diagnostic remote patient monitoring platform that seamlessly integrates into anyone's bathroom routine. By detecting early changes in a patient's urine using our toilet indwelling mass spectroscopy device, our platform is aiming to prevent hospitalizations from numerous conditions like recurrent UTIs, BPH exacerbations, or diabetes. We do this while creating significant new annual revenues for our clinician partners from remote patient monitoring reimbursements without requiring any significant changes in a staff's day to day schedule.

Personalized virtual clinical care is finally here for neurodegenerative diseases like Alzheimer's and related Dementias (Cognitive), Parkinson's and Huntington's (Movement), and ALS (Movement). We provide a novel approach to care in these diseases, centering a patient and caregiver around a coordinator who quarterbacks patients through our full Multi-Disciplinary Care Resources to local aid, PT/OT and home health support. When you leave our clinic, it's not with a handful of paper referrals, but with our coordinators helping you book and find the best physicians, DME, trials, and even cheapest prescriptions. We are devoted to helping patients, from guidance on care and insurance to providing the full spectrum of investigational and clinical testing to improve outcomes. Synapticure was built by leading patient and caregiver advocates alongside leading clinicians, biotech executives and telemedicine executives to bring the neurodegenerative disease care and treatment experience into the 21st century, and is backed by the leading Venture funds and Angel investors in the remote health and life sciences space.

Selia Connects individuals and certified psychologists and psychiatrists with an online platform for one-on-one therapy delivered via video call. Selia offers convenient and affordable access to a fully-credentialed network of highly qualified providers while giving individuals self-guided tools, journaling and mood tracking to help them achieve their goals. We created Selia to address the unmet and growing demand for mental health services for Spanish speaking Latam everywhere. Our business-to-consumer (“B2C”) channel, made of individual consumers who pay directly to our platform, and our business-to-business (“B2B”) channel, that consist from start ups to enterprise clients such as Experian, Starbucks, Habi and more

LunaJoy is building the AI-powered care platform for precision mental health—starting with women. We integrate intelligent automation with specialized clinical services to deliver scalable, life-stage-specific care—from adolescence to pregnancy, postpartum, infertility, miscarriage, perimenopause, and aging. By embedding AI agents into care navigation, triage, and decision support, we reduce costs, accelerate outcomes, and personalize treatment at scale. Our hybrid care model blends targeted psychotherapy, psychiatric medication management, genetic testing, coaching, and holistic wellness—delivered by a curated workforce of women’s mental health specialists. Through continuous feedback loops, AI segmentation, and predictive insights, LunaJoy is built to scale. We’re expanding our in-network footprint to make this care accessible across commercial and Medicaid populations—closing equity gaps for women of color, LGBTQ+ individuals, and those most at risk. Women are twice as likely to experience mental health conditions, and 3x more likely to endure trauma. Yet the system is still built for the “average” patient—ignoring the biological, emotional, and social complexity of women’s lives. LunaJoy is rearchitecting that system with AI at its core—because when we invest in women’s mental health, entire communities thrive.

US hospitals and clinics are losing $125B every year due to delayed and inaccurate medical coding. Arintra is solving this problem by automating medical coding using clinical AI. Arintra converts a patient chart instantly into insurance claims with 96% accurate medical codes and zero human intervention. Arintra has partnered with several provider clients that includes health systems and large physician groups with 100% success. Through automation of these charts, Arintra has reduced undercoding by 11% and coding-related claim denials by 43%. Arintra is headquartered in Austin, Texas. Arintra is bi-directionally integrated with leading EHRs including Epic, Athena, Cerner, etc. to process patient charts directly from the EHR to create a direct-to-billing claim. This direct-to-billing claim includes precise E/M levels, CPT, ICD-10, HCC, HCPCS codes with appropriate modifiers and units. Both founders have PhDs in AI, significant ML and NLP experience, 60+ patents and publications, and a combined 20+ years of experience working at B2B companies and startups in Silicon Valley.

Oto’s digital programs are the best way to manage tinnitus, and at a fraction of the cost of in person treatment. Tinnitus or ringing in the ears affects 1 in 8 people, and before Oto effective therapy was only available via expensive meetings with a specialist.

Navigating chronic illness is an isolating and lonely process which ultimately reduces medical adherence and adversely impacts outcomes. There are over 100 deadly chronic conditions as 1 out of 2 Americans is currently living with at least 1 chronic condition. The US healthcare system has over $1 trillion dollars in direct costs. Medical adherence rates for therapeutic programs and medicine are only 50% because patients feel lonely, isolated, and unsupported in their chronic illness journey. Reviving Mind is an in-network telehealth provider that improves clinical outcomes and program adherence for the senior medicare and medicare-advantage population that is plagued with loneliness and chronic illness. This is done through a novel and proprietary clinical program and technology platform that integrates virtual, private, curated, and professionally led groups that scale up to 8-patients with individualized and goal oriented lifestyle medicine coaching that is automated but managed by a licensed provider. Scaling rapidly across the United States.

Equipt Health makes it easy for any healthcare company to offer prescription medical devices to patients. We handle the whole process: the packaging, the logistics, the clinical (via our provider network) and technical support, and the return of data from connected devices. We're starting with the diagnosis and treatment of sleep apnea at heliosleep.com.

Intellect is the global leader in hyperlocalised mental healthcare, serving 4 million lives across enterprise employers, insurers, healthcare systems, and governments in over 50 languages and 100 countries. With a comprehensive, AI-powered care ecosystem, Intellect seamlessly integrates digital therapeutics, virtual therapy, high-acuity crisis support, and specialty clinical treatment - delivered through its proprietary digital platforms and directly owned mental health clinics. Headquartered in Singapore with nine global offices, Intellect is backed by top investors including Tiger Global, Y Combinator, Insignia Ventures, and HOF Capital. It is trusted by hundreds of Fortune 500 companies and industry leading organisations.

Pillar is designed to solve healthcare’s longitudinal engagement problem through a combination of our SOC 2-certified, HIPAA-compliant platform and health coach workforce. Our white-label infrastructure enables companies to guide patients from outreach and activation through to flexible microsites and automated digital pathways including content, services, vendors and forms. Together with our in-house network of 1,200+ health coaches, Pillar partners drive positive outcomes through scalable digital care programs focused on health education and care navigation to chronic condition management.