Mindstate Design Labs is building the closed-loop science & engineering stack for rational psychoactive effect design. Our molecular-experience interface links molecular biology to the human psychopharmacodynamic profile to convert informal constructs like clarity, presence, or motivation into high-dimensional design targets. Our clinical program is a sequence of human demonstrations that psychoactive effects can be decomposed, recombined, and synthesized. The first controlled study decomposed hallucinations from the broader hallucinogen profile; the next is designed to selectively upregulate aesthetic salience to treat anhedonia in major depressive disorder. We’re progressively digitizing the molecular interface through which biology shapes what intelligence wants.