Y Combinator Startups in the San Francisco Bay Area 2026

March 2026

Browse 2017 of the top startups funded by Y Combinator. Headquartered in the San Francisco Bay Area, these are some of the hottest and fastest-growing startups. This doesn't include all companies originally founded in San Francisco Bay Area or by founders from there.

We also have a Startup Directory where you can search through over 5,000 companies.

  • Deel
    Deel
    Y Combinator LogoW2019
    Active • 5,000 employees • San Francisco, CA, USA
    Deel is the all-in-one payroll and HR platform for global teams. Built for the way the world works today, Deel combines HRIS, payroll, compliance, benefits, performance, and equipment management into one seamless platform. With AI-powered tools and a fully owned payroll infrastructure, Deel supports every worker type in 120+ countries—helping businesses scale smarter, faster, and more compliantly. Discover how Deel makes global work simple at deel.com.
    hr-tech
    b2b
    saas
    payroll
    fintech
  • Newfront
    Newfront
    Y Combinator LogoW2018
    Active • 800 employees • San Francisco, CA, USA
    Newfront is building the modern insurance brokerage. Transparent data delivered real-time translates into a lower total cost of risk and greater insights. We work with 20% of US unicorns, 100s of YC startups, and 150+ public companies on their Business Insurance and Total Rewards. Headquartered in San Francisco, Newfront has more than 800 colleagues and offices throughout the US.
    insurance
    fintech
  • Brex
    Brex
    Y Combinator LogoW2017
    Active • 1,000 employees • San Francisco, CA, USA
    Brex is the AI-powered spend platform for modern companies, from startups to enterprises. Combining corporate cards, expense management, travel, business accounts, and bill pay, Brex makes it easy to control spend before it happens with unprecedented efficiency and accuracy. Our mission is to empower employees anywhere to make better financial decisions, so we designed our platform to make expenses almost effortless with unrivaled automation of manual expense work and real-time tracking. Brex supports more countries and currencies than any other spend solution. Brex has tens of thousands of customers, including some of the most successful, high-growth companies, such as DoorDash, SeatGeek, Coinbase, ScaleAI, MasterClass, Indeed, Allbirds, and Superhuman. Brex offers: - Corporate cards with 10-20x higher limits - Business accounts with easy wires, same-day liquidity, fast global payments, and $6M in FDIC insurance - Reward options that include billboards, offsites, and coaching - Founder-friendly financial modeling tools - Special events and masterclasses for founders - Advanced spend management software as startups grow that includes global capabilities, travel, bill pay and more.
    fintech
  • Faire
    Faire
    Y Combinator LogoW2017
    Active • 900 employees • San Francisco, CA, USA
    Faire is an innovative online marketplace that uses machine learning to match local retailers with the brands and products that uniquely fit their stores. We are using the power of technology to connect brands and independent retailers from all over the world, building a thriving community of hundreds of thousands of retailers, which has resulted in over 7 million new connections to date. Faire was founded on the belief that the future of retail is local. Our mission is to empower brands and retailers to strengthen the unique character of local communities. Our data-driven approach unburdens retailers from decades-old obstacles by helping find the right products for their shop. Plus, our straight-forward financial terms level the playing field by eliminating inventory risk and providing access to capital—key offerings previously only available to big box chains. For brands, our platform provides powerful sales, marketing, and analytics tools that simplify their business and allow them to focus on what they love: making great products.
    marketplace
    retail
  • Clipboard
    Clipboard
    Y Combinator LogoW2017
    Active • 1,000 employees • San Francisco, CA, USA
    We exist to lift as many people up the socioeconomic ladder as possible. We dramatically improve lives by letting professionals turn extra time and ambition into career growth and financial opportunity. We achieve this with our app-based marketplace that connects workplaces and professionals, allowing professionals to book on-demand shifts and workplaces to access on-demand talent.
    health-tech
    healthcare
    consumer-health-services
    marketplace
  • Rippling
    Rippling
    Y Combinator LogoW2017
    Active • 2,500 employees • San Francisco, CA, USA
    Rippling gives businesses one place to run HR, IT, and Finance. It brings together all of the workforce systems that are normally scattered across a company, like payroll, expenses, benefits, and computers. For the first time ever, you can manage and automate every part of the employee lifecycle in a single system. Take onboarding, for example. With Rippling, you can hire a new employee anywhere in the world and set up their payroll, corporate card, computer, benefits, and even third-party apps like Slack and Microsoft 365—all within 90 seconds. Based in San Francisco, CA, Rippling has raised $1.2B from the world’s top investors—including Kleiner Perkins, Founders Fund, Sequoia, Greenoaks and Bedrock.
    hr-tech
  • Scale AI
    Scale AI
    Y Combinator LogoS2016
    Active • 500 employees • San Francisco, CA, USA
    Scale accelerates the development of AI within organizations of any size to deliver critical business insights and operational efficiency. Its data-centric infrastructure platform leverages RLHF (Reinforced Learning with Human Feedback) to help organizations build the strongest AI models that supercharge their business, with customers across industries including Meta, Microsoft, U.S. Army, DoD’s Defense Innovation Unit, Open AI, General Motors, Toyota Research Institute, Brex, Instacart and Flexport.
    artificial-intelligence
    machine-learning
  • Go1
    Go1
    Y Combinator LogoS2015
    Active • 650 employees • San Francisco, CA, USA
    In today’s environment, employees need training to ensure business compliance, skill development and to support an engaged workforce. Go1 brings together content from the world’s top training providers and makes it easy to access in whichever platform your organization uses. This makes it easier to deliver, manage and engage with training. Go1 also works with existing LMS, HRIS, and business systems to make learning simpler and more effective.
    elearning
  • GitLab
    GitLab
    Y Combinator LogoW2015
    Public • 2,000 employees • San Francisco, CA, USA
    GitLab is the first single application for the entire DevOps lifecycle. Only GitLab enables Concurrent DevOps, unlocking organizations from the constraints of today’s toolchain. GitLab provides unmatched visibility, radical new levels of efficiency and comprehensive governance to significantly compress the time between planning a change and monitoring its effect. This makes the software lifecycle 200% faster, radically improving the speed of business. GitLab and Concurrent DevOps collapses cycle times by driving higher efficiency across all stages of the software development lifecycle. For the first time, Product, Development, QA, Security, and Operations teams can work concurrently in a single application. There’s no need to integrate and synchronize tools, or waste time waiting for handoffs. Everyone contributes to a single conversation, instead of managing multiple threads across disparate tools. And only GitLab gives teams complete visibility across the lifecycle with a single, trusted source of data to simplify troubleshooting and drive accountability. All activity is governed by consistent controls, making security and compliance first-class citizens instead of an afterthought. Built on Open Source, GitLab leverages the community contributions of thousands of developers and millions of users to continuously deliver new DevOps innovations. More than 100,000 organizations from startups to global enterprise organizations, including Ticketmaster, Jaguar Land Rover, NASDAQ, Dish Network and Comcast trust GitLab to deliver great software at new speeds.
    open-source
    developer-tools
    devsecops
  • GrubMarket
    GrubMarket
    Y Combinator LogoW2015
    Active • 4,548 employees • San Francisco, CA, USA
    GrubMarket is the AI-powered technology enabler and digital transformer of American Food Supply Chain industry. Our mission is to build and provide the eCommerce and software technologies to this industry, to transform this completely offline and highly manual industry into modernized online industry powered by software technologies, and improve the efficiency of American food supply chain.
    agriculture
    food-tech
    e-commerce
    supply-chain
  • Oklo
    Oklo
    Y Combinator LogoS2014
    Public • 50 employees • Santa Clara, CA, USA
    About Oklo Inc.: Oklo Inc. (Oklo) is developing advanced fission power plants to provide emission-free, reliable, and affordable energy. Oklo received a Site Use Permit from the U.S Department of Energy, has performed successful prototypic fuel fabrication, was awarded fuel material from Idaho National Laboratory, developed the first advanced fission combined license application accepted and docketed by the U.S. Nuclear Regulatory Commission, and is developing advanced fuel recycling technologies in collaboration with the U.S. Department of Energy and national laboratories. Oklo has been featured in Time, Newsweek, Wall Street Journal, CNBC, Popular Mechanics, Wired, Architectural Digest, Hyperallergic, POWER Magazine, has been the subject of a Harvard Business School case, and is featured in the Oliver Stone documentary Nuclear, among other features.
    climate
    small-modular-reactors
  • Checkr
    Checkr
    Y Combinator LogoS2014
    Active • 800 employees • San Francisco, CA, USA
    Checkr builds people infrastructure for the future of work. And we believe everyone should have a fair chance to work. That's why we've designed a faster—and fairer—way to screen job seekers. For more information on our mission and products, visit https://checkr.com.
    compliance
    enterprise-software
    api
    hr-tech
    artificial-intelligence
  • Algolia
    Algolia
    Y Combinator LogoW2014
    Active • 810 employees • San Francisco, CA, USA
    Our mission is to make every search interaction meaningful & rewarding, through developer-friendly and enterprise-grade APIs. Algolia is the leading Search & Discovery API for websites and mobile apps. We help the most innovative companies across e-commerce, media and SaaS industries create powerful, relevant and scalable discovery experiences for their users. Unlike other solutions, our hosted platform reduces the complexities of building and scaling a fast, relevant digital experience and helps teams accelerate development time. More than 9,000 companies like Under Armour, Twitch, Periscope, Medium and Stripe rely on Algolia to manage 50+ billion search queries a month. Founded in 2012, we're backed by $184M in funding from Accel Partners, Alven Capital, Point Nine Capital and Storm Ventures. The team is headquartered in San Francisco with offices in Paris, London, New York, and Atlanta. To learn more, visit www.algolia.com. --- We’re looking for talented, passionate people to build the world’s best search technology. As an ownership-driven company, we seek team members who thrive under autonomy and diversity. We're committed to building an inclusive and diverse workplace. We care about each other and the world around us, and embrace talented people regardless of their race, age, ancestry, religion, sex, gender identity, sexual orientation, marital status, color, veteran status, disability and socioeconomic background
    developer-tools
    saas
    b2b
  • Flexport
    Flexport
    Y Combinator LogoW2014
    Active • 3,000 employees • San Francisco, CA, USA
    Founded in 2013, we believe trade can move the human race forward. That’s why our mission at Flexport is to make global trade easy for everyone. What the internet has done for bits and bytes, Flexport is doing for physical goods: giving every business the ability to connect to any customer, wherever they are in the world. That sounds pretty straightforward, but a fragmented and inefficient global supply chain has held the world back from untapped growth and innovation. By connecting everyone in the global economy we can unlock commerce, creativity, and human progress. To do so, we’re building the platform for global logistics—empowering buyers, sellers and their logistics partners with the technology and services they need to grow and innovate. Today, we work with more than 40,000 customers and their suppliers across industries like manufacturing, retail, electronics, consumer goods, tech, apparel, and beauty. Companies of all sizes—from emerging brands to Fortune 500s—used Flexport technology to move nearly $19B of merchandise across 112 countries in 2021. Interested in joining our team? Check out our open job postings on careers site and apply directly today! https://www.flexport.com/careers/jobs/
    supply-chain
    saas
    logistics
  • Bellabeat
    Bellabeat
    Y Combinator LogoW2014
    Active • 134 employees • San Francisco, CA, USA
    Founded in 2014, Bellabeat is a data-centered wellness femtech company behind some of the most fashionably designed tech-powered wellness products and one of the fastest-growing wellness subscription services for women. Throughout the years, Bellabeat built the go-to wellness brand with a compelling ecosystem of solutions and services focused on women’s health. The success of the Leaf and Ivy wearables enabled the brand to expand to international markets and kickstart industry discussions on the importance of innovating in the design and development of tech products. Today, Bellabeat is leading the market shift with hyper-personalized holistic wellness offerings aligned with a women’s menstrual cycle.
    femtech
    fitness
    health-&-wellness
  • Webflow
    Webflow
    Y Combinator LogoS2013
    Active • 600 employees • San Francisco, CA, USA
    Webflow is the leading no-code visual web development platform. It seamlessly generates sophisticated code so anyone can build powerful web-based businesses and adapt to changes without developers or months of building. From entrepreneurs and creative agencies to Fortune 500 companies, Webflow makes the internet a more inclusive place by making the tools to build on it more accessible to more people, fueling business growth. Webflow powers websites for innovators like Discord, Monday.com, IDEO, Orange Theory Fitness, TED, and Dropbox. Webflow is backed by Y Combinator, Accel, CapitalG, Silversmith, and other awesome investors.
    saas
    marketing
    design
  • DoorDash
    DoorDash
    Y Combinator LogoS2013
    Public • 8,600 employees • San Francisco, CA, USA
    Founded in 2013, DoorDash is a San Francisco-based technology company passionate about transforming local businesses and dedicated to enabling new ways of working, earning, and living. Today, DoorDash connects customers with their favorite local and national restaurants in more than 600 cities across the United States and Canada. By building intelligent, last-mile delivery technology for local cities, DoorDash aims to connect people with the things they care about — one dash at a time. Read more at blog.doordash.com, and find us on Glassdoor.
    e-commerce
    marketplace
  • Fivetran
    Fivetran
    Y Combinator LogoW2013
    Active • 1,200 employees • Oakland, CA, USA
    Fivetran automates data movement out of, into and across cloud data platforms. We automate the most time-consuming parts of the ELT process from extracts to schema drift handling to transformations, so data engineers can focus on higher-impact projects with total pipeline peace of mind. With 99.9% uptime and self-healing pipelines, Fivetran enables hundreds of leading brands across the globe, including Autodesk, Conagra Brands, JetBlue, Lionsgate, Morgan Stanley, and Ziff Davis, to accelerate data-driven decisions and drive business growth. Fivetran is headquartered in Oakland, California, with offices around the world. 
    data-engineering
    saas
    analytics
    b2b
  • Instacart
    Instacart
    Y Combinator LogoS2012
    Public • 3,000 employees • San Francisco, CA, USA
    Instacart is the North American leader in online grocery and one of the fastest-growing companies in e-commerce. Instacart’s same-day delivery and pickup services bring fresh groceries and everyday essentials to busy people and families across the U.S. and Canada in as fast as an hour. Since its founding in 2012, Instacart has become an essential service for millions of families, while also serving as an immediate, flexible earnings opportunity for hundreds of thousands of shoppers across North America. The company partners with more than 350 retailers and delivers from more than 25,000 stores across more than 5,500 cities in North America. Today, Instacart is accessible to more than 85% of households in the U.S. and more than 70% of households in Canada.
    e-commerce
    grocery
    delivery
  • Benchling
    Benchling
    Y Combinator LogoS2012
    Active • 750 employees • San Francisco, CA, USA
    Biotechnology is rewriting life as we know it, from the medicines we take, to the crops we grow, the materials we wear, and the household goods that we rely on every day. Biotech R&D is radically transforming our world, but to move at the new speed of science, scientists need better technology. Benchling’s mission is to unlock the power of biotechnology. The world’s biotech leaders and innovators use our R&D Cloud to power the development of breakthrough products and accelerate time to milestone and market.
    b2b
    saas
    biotech
  • Zapier
    Zapier
    Y Combinator LogoS2012
    Active • 700 employees • Mountain View, CA, USA
    Founded in 2011, Zapier is the #1 workflow automation platform for small and mid-sized businesses. By connecting more than 6,000 of the most popular work apps, Zapier empowers its users to make the most of the tools they already use—and to focus on what matters most.
    saas
    b2b
    automation
  • Coinbase
    Coinbase
    Y Combinator LogoS2012
    Public • 6,112 employees • San Francisco, CA, USA
    Founded in June of 2012, Coinbase is a digital currency wallet and platform where merchants and consumers can transact with new digital currencies like bitcoin, ethereum, and litecoin. Our vision is to bring more innovation, efficiency, and equality of opportunity to the world by building an open financial system. Our first step on that journey is making digital currency accessible and approachable for everyone. Two principles guide our efforts. First, be the most trusted company in our domain. Second, create user-focused products that are easier and more intuitive to use.
    crypto-web3
  • Scribd
    Scribd
    Y Combinator LogoS2006
    Active • 300 employees • San Francisco, CA, USA
    Scribd gives you access to millions of ebooks, audiobooks, magazines, podcasts, and more — all in one place, for one price. OUR VISION Inspire the world through stories and knowledge. OUR MISSION Build the largest and most accessible library connecting storytellers with their audience. If you love working with smart, motivated people, you’ll love working at Scribd. We value our employees, we demonstrate accountability, and we take action. We’re one team with a common goal: helping our customers flourish.
    ai-enhanced-learning
    edtech
    remote-work
  • Dropbox
    Dropbox
    Y Combinator LogoS2007
    Public • 4,000 employees • San Francisco, CA, USA
    Dropbox is building the world’s first smart workspace. Back in 2007, making work better for people meant designing a simpler way to keep files in sync. Today, it means designing products that reduce busywork so you can focus on the work that matters. Most “productivity tools” get in your way. They constantly ping, distract, and disrupt your team’s flow, so you spend your days switching between apps and tracking down feedback. It’s busywork, not the meaningful stuff. We want to change this. We believe there’s a more enlightened way to work. Dropbox helps people be organized, stay focused, and get in sync with their teams.
  • Airbnb
    Airbnb
    Y Combinator LogoW2009
    Public • 6,132 employees • San Francisco, CA, USA
    Founded in August of 2008 and based in San Francisco, California, Airbnb is a trusted community marketplace for people to list, discover, and book unique accommodations around the world — online or from a mobile phone. Whether an apartment for a night, a castle for a week, or a villa for a month, Airbnb connects people to unique travel experiences, at any price point, in more than 33,000 cities and 192 countries. And with world-class customer service and a growing community of users, Airbnb is the easiest way for people to monetize their extra space and showcase it to an audience of millions. No global movement springs from individuals. It takes an entire team united behind something big. Together, we work hard, we laugh a lot, we brainstorm nonstop, we use hundreds of Post-Its a week, and we give the best high-fives in town. Headquartered in San Francisco, we have satellite offices in Dublin, London, Barcelona, Paris, Milan, Copenhagen, Berlin, Moscow, São Paolo, Sydney, and Singapore.
    travel
    marketplace
  • Mixpanel
    Mixpanel
    Y Combinator LogoS2009
    Active • 410 employees • San Francisco, CA, USA
    Mixpanel is analytics for builders that need answers from their data at their fingertips. When everyone in the organization can see — and learn from — the impact of their work, they are poised to make better decisions. Companies like OpenAI, Netflix, Pinterest, sweetgreen, CNN, samsara, Uber, and Yelp use Mixpanel to understand their customers, measure progress, and endeavor to make better decisions.
    analytics
    databases
    cloud-computing
    data-visualization
    b2b
  • Stripe
    Stripe
    Y Combinator LogoS2009
    Active • 7,000 employees • San Francisco, CA, USA
    Launched out of Y Combinator’s 2009 Summer batch, Stripe is a global technology company that builds economic infrastructure for the internet. Businesses of every size—from new startups to public companies—use our software to accept payments and manage their businesses online Stripe is a proud partner of YC companies—from Airbnb (S09) to Defog (W23)—to help them grow their businesses and increase the GDP of the internet.
    fintech
    banking-as-a-service
    saas
  • PagerDuty
    PagerDuty
    Y Combinator LogoS2010
    Public • 950 employees • San Francisco, CA, USA
    PagerDuty is an operations performance platform delivering visibility and actionable intelligence across the entire incident lifecycle. Their SaaS-based solution empowers over 10,000 small, mid-size and enterprise global customers such as Comcast, eHarmony, Slack and Lululemon with the insight to intelligently respond to critical disruptions for exceptional customer experience. PagerDuty was founded to deliver a new and innovative approach to increase business response and efficiency. When brand reputation depends on customer satisfaction, PagerDuty arms businesses with the insight to proactively manage incidents and events that may impact customers across their IT environment.
    monitoring
    devops
  • Amplitude
    Amplitude
    Y Combinator LogoW2012
    Public • 750 employees • San Francisco, CA, USA
    Since graduating from YC, Amplitude (W12) has made it to IPO and beyond by helping cutting edge startups become category leaders. We’ve pioneered the digital analytics category to become the go-to solution for AI pioneers (Cruise, Midjourney), apps that touch millions of consumers (Doordash, Coinbase), and the best in B2B (Atlassian, Rippling, Canva). With product analytics, experiment, CDP, session replay, and more, Amplitude’s digital analytics platform shows you what your users love, where they’re getting stuck, and what keeps them coming back. You want to build a generational business, and we have the capabilities and pricing plans to guide you every step of the way. Check out our special deal for YC companies and get started on your analytics journey.
    b2b
    analytics
    data-visualization
    developer-tools
    marketing
  • Matterport
    Matterport
    Y Combinator LogoW2012
    Public • 201 employees • Sunnyvale, CA, USA
    Matterport is an immersive media technology company that is shaking up the 3D / VR world. Our team has built the first end-to-end system for creating, modifying, distributing, and navigating immersive 3D and virtual reality (VR) versions of real-world spaces on web and mobile devices. Matterport offers the world's most inexpensive and simplest way to capture 3D spaces. Our products include: - Matterport Pro Camera for capturing real spaces in 3D. It collects accurate visual and spatial data to map entire areas in minutes and is all about automation and ease of use. - The Matterport Cloud for processing and hosting 3D models - Matterport Portal, our system for viewing, editing, and managing models; collaborating with colleagues; and sharing models with others - Matterport 3D Showcase, a browser-based 3D media player, which allows anyone to view 3D models in their browser with no additional software - Matterport Core VR: All Spaces can be converted to VR and experienced on Samsung Gear VR or Google Cardboard (in beta), with additional device support coming soon. Matterport 3D media solutions power industries from real estate (residential, multi-family and commercial) and travel and hospitality (hotels, vacation rentals, and venue booking), to business listings, architecture, engineering and construction, news and entertainment, and everything in between. We’re growing fast. If you’re passionate about solving cutting-edge problems in computer vision and hardware design and creating order-of-magnitude improvements in the ability to easily create and share 3D models of real world spaces, we want to talk to you. See open positions at matterport.com/jobs. Try Matterport for yourself at matterport.com/try.
    computer-vision
  • Gusto
    Gusto
    Y Combinator LogoW2012
    Active • 2,400 employees • San Francisco, CA, USA
    Launched in 2012 as ZenPayroll, Gusto serves more than 300,000 businesses nationwide. Each year we process tens of billions of dollars of payroll and provide employee benefits—like health insurance and 401(k) accounts—while helping companies create incredible work places. Through one refreshingly easy, integrated platform, we automate and simplify your payroll, benefits, and HR, all while providing expert support. You and your employees will get the peace of mind you need to do your best work.
    b2b
    payroll
    health-insurance
  • Reddit
    Reddit
    Y Combinator LogoS2005
    Acquired • 2,000 employees • San Francisco, CA, USA
    Founded by Steve Huffman and Alexis Ohanian in 2005, Reddit is an online community where users submit, vote, and comment on content, news, and discussions. Nicknamed "the front page of the internet,"​ Reddit is one of the top ten sites in the United States (source: Alexa), with hundreds of millions of users each month on desktop, mobile web, and our official Android/iOS apps. Interested in joining our growing team? Check out about.reddit.com/careers
    community
    social
    social-media
    social-network
  • Optimizely
    Optimizely
    Y Combinator LogoW2010
    Acquired • 1,500 employees • San Francisco, CA, USA
    At Optimizely, we're on a mission to help people unlock their digital potential. We do that by reinventing how marketing and product teams work to create and optimize digital experiences across all channels. With Optimizely One, our industry-first operating system for marketers, we offer teams flexibility and choice to build their stack their way with our fully SaaS, fully decoupled, and highly composable solution. We help companies around the world orchestrate their entire content lifecycle, monetize every digital experience and experiment across all customer touchpoints – all through Optimizely One, the leading digital experience platform that powers every phase of the marketing lifecycle through a single, AI-accelerated workflow. Optimizely has nearly 1500 employees across our 21 global offices and has 700+ partners. We are proud to help more than 10,000 businesses, including H&M, PayPal, Zoom, and Toyota, enrich their customer lifetime value, increase revenue and grow their brands. At Optimizely, we live each day with a simple philosophy: large enough to serve, small enough to care. Learn more at optimizely.com.
    marketing
  • BioStack Platforms
    BioStack Platforms
    Y Combinator LogoP2026
    Active0 • San Francisco, CA, USA
    BioStack is building the data engine for healthcare and drug discovery AI. The bottleneck is not models. It is access to high-quality biological data. Clinical and experimental data is fragmented, unstructured, and locked inside hospitals, labs, and CROs, while generating new data is slow and expensive. BioStack fixes this with proprietary clinical and preclinical data pipelines that turn real biomedical workflows into ML-ready training environments. We structure longitudinal multimodal data across imaging, EHR, and experimental assays, then package it for post-training and reinforcement learning so models can learn how research and care actually happen. Instead of static datasets, BioStack gives AI labs workflow-aligned data and environments that improve reasoning, decision-making, and real-world performance in biology and medicine.
    ai-powered-drug-discovery
    reinforcement-learning
    healthcare
  • Sazabi
    Sazabi
    Y Combinator LogoP2026
    Active • 10 employees • San Francisco, CA, USA
    The AI-native observability platform for fast-moving engineering teams. Backed by tastemakers from the world's top AI companies: Vercel, Graphite, Daytona, Browserbase, LangChain, Mastra, Replit, and more.
    developer-tools
  • InventoryQuant
    InventoryQuant
    Y Combinator LogoW2026
    Active • 1 employees • San Francisco, CA, USA
    We automate inventory and contents processing for insurance and insurance-adjacent industries, including public adjusters, restoration contents, and insurance companies. We also handle various inventory and estimate adjacent processes that cost many billions of dollars a year and thousands of years of man hours.
    insurance
    ai
  • Alchemy
    Alchemy
    Y Combinator LogoP2026
    Active • 2 employees • San Francisco, CA, USA
    Alchemy automates image analysis for life science researchers who spend hours every day turning images into useful numerical data, often manually. Through a combination of our customized pipeline tailored to the researcher's needs and our suite of ML models, we've helped labs reduce analysis time by over 90%, while enabling analyses that were previously impossible. All a researcher has to do is upload their images, describe what you need in plain language, and our agents help assemble your tailored analysis pipeline, selects the right models for your specific images, and lets you verify every step before exporting reproducible, publication-ready results.
    biotech
    machine-learning
    saas
    automation
    ai-powered-drug-discovery
  • Prototyping.io
    Prototyping.io
    Y Combinator LogoP2026
    Active • 2 employees • Sunnyvale, CA, USA
    Prototyping.io is a manufacturing intelligence platform that understands mechanical designs, identifies manufacturability issues early, provides actionable insights and delivers custom mechanical parts (CNC machining, sheet metal, 3D printing, injection molding, etc.) with faster lead times, lower cost, and high quality.
    manufacturing
    hardware
    ai
  • Amboras
    Amboras
    Y Combinator LogoP2026
    Active • 4 employees • San Francisco, CA, USA
    Amboras puts your entire e-commerce on autopilot. It builds your store, continuously optimizes it, reads your analytics, and learns what converts - all autonomously. No developers. No agencies. No guessing. Today it sells to humans. Tomorrow it sells to AI agents.
    b2b
    e-commerce
    generative-ai
  • OpenWork
    OpenWork
    Y Combinator LogoP2026
    Active • 4 employees • San Francisco, CA, USA
    OpenWork is a desktop app that lets people connect to their existing skills, MCPs, and agents. Users can download the app for free, try it with over 50+ model providers, and easily share their setup with their team.
    b2b
  • Kimpton AI
    Kimpton AI
    Y Combinator LogoP2026
    Active • 5 employees • San Francisco, CA, USA
    Kimpton is an AI-native investment research platform built by ex-quant fund operators. Instead of analysts staring at screens hunting for edge, Kimpton's system is a comprehensive agentic harness containing the context that matters to investors: real-time and historical data across 120,000+ assets, company fundamentals fragmented intelligence sources, and your actual portfolio from 2,500+ brokerages. It conducts the research autonomously: visualizing, backtesting, forecasting with prediction markets, and proposing structured trades tailored to your thesis and risk profile. Built by former hedge fund operators who spent years building this stack for themselves, Kimpton makes the CIO role accessible to every investor. Humans make the decisions. AI does everything else.
    fintech
  • Clara
    Clara
    Y Combinator LogoP2026
    Active • 9 employees • San Francisco, CA, USA
    Clara is an AI primary care and longevity practice from the team that founded and grew Circle Medical to $100M in revenue. Our mission at Clara is to add one billion years of healthspan to humanity. We do this with an AI with deep clinical knowledge, coupled with the ability to sift through medical data to detect trends and patterns that could be missed. Unlike Claude or ChatGPT, Clara can see your medical data and then act. Chat with Clara as you would a doctor and Clara can help with you make sense of symptoms, get medication refills, order and understand labs, and achieve health goals. Medical recommendations are preliminary until one of our human medical providers in the loop reviews and approves them.
    healthcare
    telemedicine
    telehealth
    ai
  • Runtime
    Runtime
    Y Combinator LogoP2026
    Active • 3 employees • San Francisco, CA, USA
    Runtime (runtm.com) gives engineering teams control and visibility to enable anyone in their org to use coding agents securely. Eng leaders rolling out coding agents have no way to see what's happening, set boundaries, or safely let non-engineers use them. We provide sandboxed environments, session-level observability, and configurable guardrails so anyone on your team can ship with coding agents without breaking prod. We're live with fast-growing YC scaleups empowering their PMs, designers, marketers, and ops to contribute to their codebase or build prod-grade zero-to-one apps.
    developer-tools
    artificial-intelligence
  • Kinro
    Kinro
    Y Combinator LogoP2026
    Active • 3 employees • San Francisco, CA, USA
    Kinro helps companies sell insurance through AI assistants such as ChatGPT. We build AI sales agents that manage the end-to-end insurance sales process, from answering questions, personalized coverage explanations and quoting. These agents are continuously evaluated and improved through our proprietary platform, optimizing sales performance while remaining 100% compliant. Selling insurance requires strict regulatory compliance, deep carrier integrations, and extremely reliable answers. Platforms like OpenAI and Google remain general-purpose and are less likely to build the vertical infrastructure required for regulated industries. Today, Kinro serves brokers and direct-to-consumer carriers across the US and Europe. Insurance distribution is huge: insurers pay roughly $100B+ in commissions annually, and distributors spend $10B+ every year on advertising to acquire customers. Pierre-Alexandre led research improving Gemini for financial services at DeepMind. Parth led infrastructure for training and inference at Zoox. Corentin was the first employee in an insurance startup and worked closely with many insurance leaders.
    b2b
    insurance
    conversational-ai
  • matforge
    matforge
    Y Combinator LogoP2026
    Active • 2 employees • San Francisco, CA, USA
    We build AI scientists that discover new materials for the semiconductor industry - specifically datacenters and fabs. Finding novel materials today takes 10+ years of lab work. We aim to compress that timeline to months, using a swarm of AI agents. Akash completed his PhD at Stanford on material discovery for semiconductors. The materials he discovered for nanoscale interconnects have been adopted into the roadmaps of Intel and TSMC. Advaith was the founding applied scientist at Persona AI (acquired by Luma Labs), where he built long horizon autonomous agents for major telecom and crypto companies. Power consumption and heat release from AI chips is doubling every year. The semiconductor industry needs new materials to keep this exponential going - Matforge will help find them.
    ai
    advanced-materials
    semiconductors
    artificial-intelligence
  • Benchspan
    Benchspan
    Y Combinator LogoP2026
    Active • 2 employees • San Francisco, CA, USA
    Benchspan is a benchmarking platform for AI agents. If you're building an agent, you need to know if it's getting better. But running benchmarks is slow, expensive, and fragile. You spend days writing glue code every time you want to run a new benchmark, runs take forever on your laptop, and when they fail halfway through you burn hundreds of dollars in tokens with nothing to show for it. Benchspan fixes all of it. Onboard your agent once, and it works with every benchmark on the platform. We onboarded Claude Code in 37 lines of code. Running a benchmark becomes a single command, executed in parallel in the cloud. Every result goes to one place your whole team can see, with full trajectories, token usage, latency, and custom metrics. When runs partially fail, rerun just the subset that errored instead of starting from scratch. Compare runs side by side to see exactly where your agent is improving and where it's regressing.
    aiops
    analytics
    infrastructure
    ai
  • Saffron
    Saffron
    Y Combinator LogoP2026
    Active • 3 employees • San Francisco, CA, USA
    Saffron is building a platform to test how well candidates can use coding agents. The way engineers write code has fundamentally changed, but the way companies evaluate them hasn't. Saffron gives hiring teams full visibility into how candidates use AI agents to build, debug, and ship real features on an actual codebase. Saffron was founded by Robert Chondro (formerly MIT and Jane Street), Jerry Yao (Stanford and Jane Street), and Kazuma Choji (Harvey Mudd, published in NeurIPS and ICML), and is backed by Y Combinator (P26) and Afore Capital.
    saas
    human-resources
    hr-tech
  • Playabl.ai
    Playabl.ai
    Y Combinator LogoP2026
    Active • 9 employees • San Francisco, CA, USA
    Playabl.ai is an AI game builder that lets anyone create games and interactive experiences by chatting with AI.
    gaming
    b2b
    artificial-intelligence
  • TesterArmy
    TesterArmy
    Y Combinator LogoP2026
    Active • 4 employees • San Francisco, CA, USA
    TesterArmy is an AI agent that tests your web app in a real browser before code ships. It runs automatically on every GitHub Pull Request, then posts recording, pass/fail results, and failure context as a PR comment. Teams also get a CLI for local/CI runs and an API for custom pipelines. We catch the regressions that code review misses.
    ai
  • Foaster
    Foaster
    Y Combinator LogoP2026
    Active • 2 employees • San Francisco, CA, USA
    Consulting hasn’t evolved much in decades. Yet it is still slow, expensive, and built on partial visibility. AI finally makes a new model possible. At Foaster.ai, our agents interview employees at scale, reconstruct a detailed map of how the company actually works, and reason on top of it to generate recommendations. Unlike traditional consulting, which usually relies on a limited set of interviews and an incomplete view of operations, this lets us tackle much more complex problems with far greater precision. Human experts stay in the loop to validate the output, challenge the reasoning when needed, deliver the final recommendations, and improve the system over time. We can already work with companies today on: • Process mapping: map operations you have never fully understood, yet that are critical to the business • AI roadmap design: identify at scale where AI could have the highest impact across your organization • Cost reduction: surface inefficiencies buried across workflows, teams, and day-to-day operations What used to take weeks or months can now be explored in a few days, with much greater visibility into how the company actually works. And once that operational map exists, we can solve more and more business problems on top of the same foundation without starting from scratch.
    artificial-intelligence
    enterprise-software
    b2b
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